TMEM104

Across TCGA cell cohorts, TMEM104 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM104-associated genes across cancer lineages are AVP, DDX54, and OR5C1. Each is linked with TMEM104 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM104-to-partner and partner-to-TMEM104 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by TMEM104-low versus TMEM104-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM104→partner) and Y-score (partner→TMEM104) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.040	+3.047	<.001	.001	3	1
LARGE_INTESTINE	DDX54 →	+0.573	+3.299	.006	.004	3	1
LARGE_INTESTINE	OR5C1 →	+0.026	+2.378	.005	.006	3	1
LARGE_INTESTINE	CCNDBP1 →	+0.501	+3.212	.002	.006	3	1
LARGE_INTESTINE	GLOD4 →	+0.682	+3.299	.001	.004	3	1
LARGE_INTESTINE	NTSR2 →	+0.042	+2.378	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

AVP by TMEM104 expression — LARGE_INTESTINE

Explore this box plot interactively →