TMEM102

Across TCGA pan-cancer cohorts, TMEM102 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM102 data layer compared with 19 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TMEM102 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM102 expression acts as an unfavorable survival marker.

SCLC, CESC, and SKCM are the cancer types where TMEM102 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.055	0.708	<.001	36	view →
CESC	OS	Median	All	0.151	0.798	<.001	12	view →
SKCM	DFS	Median	All	0.236	0.729	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM102–SCLC (OS)

Open the SCLC breakdown →