TMEM101

Across TCGA patient cohorts, TMEM101 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM101-associated genes across cancer lineages are eIF4E, ERK2, and PDCD4. Each is linked with TMEM101 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM101-to-partner and partner-to-TMEM101 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TMEM101-low versus TMEM101-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM101→partner) and Y-score (partner→TMEM101) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.180	+2.459	.044	.019	3	1
UCEC	ERK2 →	+0.209	+3.459	.010	.005	3	1
UCEC	PDCD4 →	-0.478	-1.700	.016	.044	3	1
UCEC	PDK1_pS241 →	+0.151	+2.833	.038	.034	3	1
UCEC	Rad50 →	-0.300	-3.156	.003	.018	3	1
UCEC	ATM →	-0.745	-2.308	<.001	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by TMEM101 expression — UCEC

Explore this box plot interactively →