TMEM100

Across TCGA patient cohorts, TMEM100 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM100-associated genes across cancer lineages are p90 RSK_pT359_S363, eIF4E, and ETS-1. Each is linked with TMEM100 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM100-to-partner and partner-to-TMEM100 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK_pT359_S363 grouped by TMEM100-low versus TMEM100-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM100→partner) and Y-score (partner→TMEM100) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK_pT359_S363 →	-0.229	-3.321	.009	.009	3	2
UCEC	eIF4E →	+0.229	+3.183	.012	.009	3	1
UCEC	ETS-1 →	+0.290	+3.169	.037	.018	3	1
UCEC	GAPDH →	+0.622	+2.807	.007	.003	3	1
UCEC	GATA6 →	-0.187	-3.307	.005	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.199	-2.102	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

p90 RSK_pT359_S363 by TMEM100 expression — UCEC

Explore this box plot interactively →