TMEFF2

Across TCGA patient cohorts, TMEFF2 mutation is significantly associated with the RNA expression of many other genes, with 763 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEFF2-associated genes across cancer lineages are MIR4797, RNA5SP321, and LINC01639. Each is linked with TMEFF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEFF2-to-partner and partner-to-TMEFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4797 grouped by TMEFF2-low versus TMEFF2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEFF2→partner) and Y-score (partner→TMEFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4797 →	+0.819	+5.054	<.001	.001	3	3
CESC	RNA5SP321 →	+0.251	+5.539	<.001	.004	3	2
LUAD	LINC01639 →	+0.361	+4.202	<.001	.001	3	2
COAD	PGBD4P1 →	+0.400	+3.730	.004	.006	3	2
BLCA	OR5F1 →	+0.028	+4.718	<.001	.003	3	2
SKCM	HAUS2 →	+0.526	+2.748	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 763 associations by consensus.

MIR4797 by TMEFF2 expression — READ

Explore this box plot interactively →