TMEFF2

Across TCGA patient cohorts, TMEFF2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEFF2-associated genes across cancer lineages are ATM, Myosin-IIa_pS1943, and 14-3-3_beta. Each is linked with TMEFF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEFF2-to-partner and partner-to-TMEFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TMEFF2-low versus TMEFF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEFF2→partner) and Y-score (partner→TMEFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.502	-2.446	.003	.018	3	2
SKCM	Myosin-IIa_pS1943 →	-0.411	-2.982	.010	.036	3	1
UCEC	14-3-3_beta →	-0.077	-3.143	.045	.018	3	1
UCEC	ERK2 →	+0.196	+2.087	.008	.005	3	1
UCEC	ACC1 →	+0.322	+2.472	.021	.010	3	1
UCEC	JNK2 →	+0.203	+1.884	.007	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by TMEFF2 expression — UCEC

Explore this box plot interactively →