TMEFF2

Across TCGA cell cohorts, TMEFF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,091 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEFF2-associated GO terms across cancer lineages are Protein-DNA complex organization, Negative regulation of microtubule depolymerization, and Regulation of G2/M transition of mitotic cell cycle. Each is linked with TMEFF2 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMEFF2-to-partner and partner-to-TMEFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-DNA complex organization grouped by TMEFF2-low versus TMEFF2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEFF2→partner) and Y-score (partner→TMEFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein-DNA complex organization →	+0.090	+2.582	.001	.002	3	8
LUNG_NSCLC_LUAD	Negative regulation of microtubule depolymerization →	+0.096	+0.308	<.001	.001	1	9
SKIN	Regulation of G2/M transition of mitotic cell cycle →	+0.037	+0.653	.001	.003	3	7
LUNG_NSCLC_LUAD	Microtubule cytoskeleton organization involved in mitosis →	+0.063	+0.332	<.001	.001	3	7
LUNG_NSCLC_LUAD	Establishment of mitotic spindle localization →	+0.052	+0.344	<.001	.006	3	7
LUNG_NSCLC_LUAD	Mitotic sister chromatid segregation →	+0.052	+0.404	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,091 associations by consensus.

Protein-DNA complex organization by TMEFF2 expression — BONE

Explore this box plot interactively →