TMEFF2

Across TCGA cell cohorts, TMEFF2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMEFF2-associated genes across cancer lineages are TMEM235, IQCF6, and OR12D2. Each is linked with TMEFF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEFF2-to-partner and partner-to-TMEFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM235 grouped by TMEFF2-low versus TMEFF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEFF2→partner) and Y-score (partner→TMEFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM235 →	+0.011	+4.467	<.001	.004	3	2
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1
LARGE_INTESTINE	OR12D2 →	+0.087	+4.467	<.001	.004	3	1
LUNG_NSCLC_LUAD	SLC17A2 →	+0.006	+3.681	<.001	.009	3	1
LUNG_NSCLC_LUAD	IAPP →	+0.344	+2.965	<.001	.007	3	1
BREAST	SPZ1 →	+0.020	+3.963	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

TMEM235 by TMEFF2 expression — LARGE_INTESTINE

Explore this box plot interactively →