TMED8

Across TCGA patient cohorts, TMED8 mutation is significantly associated with the RNA expression of many other genes, with 345 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED8-associated genes across cancer lineages are RNU6-633P, RNU5E-9P, and VTRNA2-2P. Each is linked with TMED8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMED8-to-partner and partner-to-TMED8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-633P grouped by TMED8-low versus TMED8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED8→partner) and Y-score (partner→TMED8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-633P →	+0.513	+2.448	<.001	.003	3	3
UCEC	RNU5E-9P →	+0.197	+3.885	<.001	.008	3	3
UCEC	VTRNA2-2P →	+0.428	+2.374	<.001	.004	3	3
CESC	MIR3925 →	+0.515	+6.144	<.001	.001	3	2
UCEC	RNU1-28P →	+0.286	+3.162	<.001	.001	3	2
UCEC	RNA5SP369 →	+0.477	+2.778	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

RNU6-633P by TMED8 expression — UCEC

Explore this box plot interactively →