TMED8

Across TCGA patient cohorts, TMED8 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED8-associated genes across cancer lineages are PDCD4, 14-3-3_beta, and EGFR_pY1068. Each is linked with TMED8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED8-to-partner and partner-to-TMED8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by TMED8-low versus TMED8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED8→partner) and Y-score (partner→TMED8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.589	-3.169	.012	.018	3	2
UCEC	14-3-3_beta →	-0.134	-3.143	.007	.018	3	1
UCEC	EGFR_pY1068 →	-0.282	-2.321	.025	.035	3	1
UCEC	ER-alpha →	-0.894	-2.321	.030	.035	3	1
UCEC	FoxM1 →	+0.377	+2.321	.003	.035	3	1
UCEC	PRAS40_pT246 →	+0.220	+2.335	.010	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PDCD4 by TMED8 expression — UCEC

Explore this box plot interactively →