TMED8

Across TCGA cell cohorts, TMED8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,585 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMED8-associated GO terms across cancer lineages are Regulation of heterochromatin formation, Positive regulation of cilium assembly, and DNA-templated DNA replication. Each is linked with TMED8 in more than 14 cancer types. Because this analysis shows association rather than direction, both TMED8-to-partner and partner-to-TMED8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of heterochromatin formation grouped by TMED8-low versus TMED8-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED8→partner) and Y-score (partner→TMED8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of heterochromatin formation →	+0.119	+0.823	.001	.001	3	15
BLOOD_Leukemia	Positive regulation of cilium assembly →	+0.079	+1.017	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.139	+0.874	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA metabolic process →	+0.082	+0.823	<.001	<.001	3	15
SOFT_TISSUE	Double-strand break repair →	+0.073	+0.677	<.001	<.001	3	15
OESOPHAGUS	Centrosome cycle →	+0.120	+0.882	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,585 associations by consensus.

Regulation of heterochromatin formation by TMED8 expression — URINARY_TRACT

Explore this box plot interactively →