TMED8

Across TCGA cell cohorts, TMED8 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMED8-associated genes across cancer lineages are NPHS2 and ELOA3DP. Each is linked with TMED8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED8-to-partner and partner-to-TMED8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHS2 grouped by TMED8-low versus TMED8-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED8→partner) and Y-score (partner→TMED8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NPHS2 →	+0.013	+4.736	<.001	.009	3	1
LARGE_INTESTINE	ELOA3DP →	+0.031	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

NPHS2 by TMED8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →