TMED8

Across TCGA cell cohorts, TMED8 mutation is significantly associated with the mutation status of many other genes, with 1,288 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMED8-associated genes across cancer lineages are SARS1, ZNF800, and ST7. Each is linked with TMED8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED8-to-partner and partner-to-TMED8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SARS1 grouped by TMED8-low versus TMED8-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED8→partner) and Y-score (partner→TMED8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SARS1 →	+5.392	+5.392	.004	.004	1	2
UPPER_AERODIGESTIVE_TRACT	ZNF800 →	+5.392	+5.392	.004	.004	1	2
UPPER_AERODIGESTIVE_TRACT	ST7 →	+4.392	+4.954	.008	.008	1	2
UPPER_AERODIGESTIVE_TRACT	LIG3 →	+4.392	+4.954	.008	.008	1	2
UPPER_AERODIGESTIVE_TRACT	PUM2 →	+4.392	+4.954	.008	.008	1	2
UPPER_AERODIGESTIVE_TRACT	EPN1 →	+5.392	+5.392	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,288 associations by consensus.

SARS1 by TMED8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →