TMED6

Across TCGA patient cohorts, TMED6 mutation is significantly associated with the RNA expression of many other genes, with 965 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED6-associated genes across cancer lineages are IGLV1-44, IGLV3-16, and IGHV3-64. Each is linked with TMED6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED6-to-partner and partner-to-TMED6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGLV1-44 grouped by TMED6-low versus TMED6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED6→partner) and Y-score (partner→TMED6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGLV1-44 →	+2.320	+3.711	<.001	<.001	3	2
UCEC	IGLV3-16 →	+0.882	+2.606	.009	.006	3	2
UCEC	IGHV3-64 →	+1.274	+3.711	.002	<.001	3	2
UCEC	RGS17P1 →	+0.364	+2.670	.002	.005	3	2
UCEC	IGHV4-31 →	+1.730	+3.330	.005	.005	3	2
UCEC	LINC01072 →	+0.132	+3.073	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 965 associations by consensus.

IGLV1-44 by TMED6 expression — UCEC

Explore this box plot interactively →