TMED6

Across TCGA patient cohorts, TMED6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED6-associated genes across cancer lineages are ERK2, Notch1, and ATM. Each is linked with TMED6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED6-to-partner and partner-to-TMED6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TMED6-low versus TMED6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED6→partner) and Y-score (partner→TMED6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.255	+3.169	.016	.020	3	1
UCEC	Notch1 →	+0.264	+3.009	<.001	.019	3	1
UCEC	ATM →	-0.627	-3.169	.011	.020	3	1
UCEC	Bax →	+0.283	+3.169	.031	.020	3	1
UCEC	PCNA →	+0.392	+3.169	<.001	.020	2	1
UCEC	PDCD4 →	-1.005	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by TMED6 expression — UCEC

Explore this box plot interactively →