TMED5

Across TCGA patient cohorts, TMED5 mutation is significantly associated with the RNA expression of many other genes, with 2,618 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED5-associated genes across cancer lineages are RNY3P11, RNU6-647P, and RNA5SP146. Each is linked with TMED5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED5-to-partner and partner-to-TMED5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY3P11 grouped by TMED5-low versus TMED5-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED5→partner) and Y-score (partner→TMED5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNY3P11 →	+0.388	+4.306	<.001	.001	3	2
CESC	RNU6-647P →	+0.330	+4.068	<.001	.001	3	2
UCEC	RNA5SP146 →	+0.307	+2.332	<.001	.001	3	2
HNSC	MIR4307 →	+0.582	+7.954	<.001	.008	3	2
LUSC	MIR6131 →	+0.579	+5.038	<.001	.009	3	2
CESC	SAPCD2P2 →	+0.023	+4.103	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,618 associations by consensus.

RNY3P11 by TMED5 expression — CESC

Explore this box plot interactively →