TMED5

Across TCGA patient cohorts, TMED5 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED5-associated genes across cancer lineages are eIF4G, A-Raf_pS299, and ERK2. Each is linked with TMED5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED5-to-partner and partner-to-TMED5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by TMED5-low versus TMED5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED5→partner) and Y-score (partner→TMED5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.306	+2.000	.012	.010	3	1
UCEC	A-Raf_pS299 →	-0.116	-2.000	.013	.030	3	1
UCEC	ERK2 →	+0.193	+1.700	.010	.042	3	1
UCEC	FoxM1 →	+0.339	+2.502	<.001	.002	3	1
UCEC	INPP4B →	-0.298	-2.459	.018	.018	3	1
UCEC	JNK2 →	+0.321	+3.594	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eIF4G by TMED5 expression — UCEC

Explore this box plot interactively →