TMED3

Across TCGA patient cohorts, TMED3 mutation is significantly associated with the RNA expression of many other genes, with 326 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED3-associated genes across cancer lineages are OR1C1, BNIP3P35, and MIR6749. Each is linked with TMED3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED3-to-partner and partner-to-TMED3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1C1 grouped by TMED3-low versus TMED3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED3→partner) and Y-score (partner→TMED3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR1C1 →	+0.030	+4.554	.007	.009	3	2
BLCA	BNIP3P35 →	+0.098	+6.289	<.001	.001	3	1
BLCA	MIR6749 →	+0.553	+7.632	<.001	<.001	3	1
UCEC	FBXO7 →	+0.513	+3.480	.003	.002	3	1
UCEC	PHF5A →	+0.526	+3.459	.007	.005	3	1
UCEC	DHRS2 →	+1.253	+3.480	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 326 associations by consensus.

OR1C1 by TMED3 expression — LUAD

Explore this box plot interactively →