TMED3

Across TCGA patient cohorts, TMED3 mutation is significantly associated with the immune_cell of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED3-associated genes across cancer lineages are Neutrophils, Erythrocytes, and Osteoblast. Each is linked with TMED3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED3-to-partner and partner-to-TMED3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophils grouped by TMED3-low versus TMED3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED3→partner) and Y-score (partner→TMED3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Neutrophils →	+0.012	+3.197	<.001	.048	3	2
UCEC	Erythrocytes →	+0.041	+3.241	.001	.009	3	2
LUSC	Osteoblast →	+0.047	+3.538	.002	.016	3	1
UCEC	CD8+ naive T-cells →	+0.027	+2.823	.047	.036	3	1
UCEC	Adipocytes →	+0.018	+2.337	.048	.010	3	1
UCEC	Basophils →	+0.213	+2.321	.012	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Neutrophils by TMED3 expression — LUAD

Explore this box plot interactively →