TMCO6

Across TCGA cell cohorts, TMCO6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,370 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMCO6-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Double-strand break repair, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with TMCO6 in more than 15 cancer types. Because this analysis shows association rather than direction, both TMCO6-to-partner and partner-to-TMCO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by TMCO6-low versus TMCO6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO6→partner) and Y-score (partner→TMCO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Pre-mRNA catabolic process →	+0.204	+1.138	<.001	<.001	3	16
BONE	Double-strand break repair →	+0.105	+1.377	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA splicing, via spliceosome →	+0.130	+1.209	<.001	<.001	3	15
BONE	Recombinational repair →	+0.120	+1.321	<.001	<.001	3	15
BONE	Constitutive heterochromatin formation →	+0.134	+1.463	<.001	<.001	3	14
BONE	Negative regulation of RNA splicing →	+0.117	+1.335	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,370 associations by consensus.

Pre-mRNA catabolic process by TMCO6 expression — BONE

Explore this box plot interactively →