TMCO6

Across TCGA cell cohorts, TMCO6 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMCO6-associated genes across cancer lineages are ZNRF4, CD1A, and C1QTNF7. Each is linked with TMCO6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCO6-to-partner and partner-to-TMCO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNRF4 grouped by TMCO6-low versus TMCO6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO6→partner) and Y-score (partner→TMCO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNRF4 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	CD1A →	+0.025	+3.347	<.001	.005	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.134	+3.523	<.001	.002	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ZNRF4 by TMCO6 expression — LARGE_INTESTINE

Explore this box plot interactively →