TMCO3

Across TCGA pan-cancer cohorts, TMCO3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMCO3 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMCO3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TMCO3 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where TMCO3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	57	view →
LSCC	DFS	Quartile	All	0.873	0.999	.013	12	view →
PDAC	DFS	Tertile	III,IV	0.503	0.192	.015	8	view →
CCRCC	DFS	Median	All	0.662	0.810	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMCO3–HNSC (OS)

Open the HNSC breakdown →