TMCO3

Across TCGA patient cohorts, TMCO3 mutation is significantly associated with the RNA expression of many other genes, with 3,316 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCO3-associated genes across cancer lineages are GLOD4, TIMM22, and SAR1A. Each is linked with TMCO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMCO3-to-partner and partner-to-TMCO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLOD4 grouped by TMCO3-low versus TMCO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO3→partner) and Y-score (partner→TMCO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLOD4 →	+0.453	+1.765	<.001	<.001	3	3
UCEC	TIMM22 →	+0.412	+1.808	<.001	<.001	3	3
UCEC	SAR1A →	+0.296	+1.332	.005	.008	3	3
CESC	RNU6-1066P →	+0.344	+5.418	.002	.005	3	3
UCEC	BCAS2 →	+0.368	+1.343	.006	.008	3	3
UCEC	LLPH →	+0.372	+1.797	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,316 associations by consensus.

GLOD4 by TMCO3 expression — UCEC

Explore this box plot interactively →