TMCO3

Across TCGA cell cohorts, TMCO3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,827 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMCO3-associated GO terms across cancer lineages are Positive regulation of translational initiation in response to stress, Cytosolic transport, and Vesicle-mediated transport to the plasma membrane. Each is linked with TMCO3 in more than 13 cancer types. Because this analysis shows association rather than direction, both TMCO3-to-partner and partner-to-TMCO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of translational initiation in response to stress grouped by TMCO3-low versus TMCO3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO3→partner) and Y-score (partner→TMCO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of translational initiation in response to stress →	+0.159	+1.094	<.001	<.001	3	14
BONE	Cytosolic transport →	+0.083	+1.416	<.001	.001	3	13
BONE	Vesicle-mediated transport to the plasma membrane →	+0.105	+1.697	<.001	<.001	3	13
BONE	Regulation of translation in response to endoplasmic reticulum stress →	+0.182	+1.819	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.157	+0.958	<.001	.002	3	12
BONE	Regulation of intracellular transport →	+0.094	+1.624	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,827 associations by consensus.

Positive regulation of translational initiation in response to stress by TMCO3 expression — BONE

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