TMCO3

Across TCGA cell cohorts, TMCO3 mutation is significantly associated with the mutation status of many other genes, with 2,540 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMCO3-associated genes across cancer lineages are CELF4, COL7A1, and SF3B1. Each is linked with TMCO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMCO3-to-partner and partner-to-TMCO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELF4 grouped by TMCO3-low versus TMCO3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO3→partner) and Y-score (partner→TMCO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CELF4 →	+5.303	+4.339	<.001	<.001	1	3
BLOOD_Leukemia	COL7A1 →	+2.465	+3.686	.001	.001	1	3
LUNG_NSCLC_LUAD	SF3B1 →	+2.981	+3.266	.009	.009	1	3
LARGE_INTESTINE	F13A1 →	+2.807	+2.954	.001	.001	1	3
LARGE_INTESTINE	SPECC1 →	+1.691	+2.479	.008	.008	1	3
LARGE_INTESTINE	PER2 →	+2.807	+2.954	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,540 associations by consensus.

CELF4 by TMCO3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →