Across TCGA patient cohorts, TMCO2 mutation is significantly associated with the RNA expression of many other genes, with 372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCO2-associated genes across cancer lineages are RNA5SP249, YPEL5P2, and C17orf98. Each is linked with TMCO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCO2-to-partner and partner-to-TMCO2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO2→partner) and Y-score (partner→TMCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP249 →	+0.305	+4.300	<.001	.005	3	2
UCEC	YPEL5P2 →	+0.484	+3.956	<.001	<.001	3	1
UCEC	C17orf98 →	+0.414	+3.729	.009	.001	3	1
UCEC	HES7 →	+0.273	+3.643	.003	.003	3	1
UCEC	SPATA12 →	+0.515	+3.364	.001	.005	3	1
UCEC	KIR2DL4 →	+0.817	+3.364	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 372 associations by consensus.

Exploration

TMCO2 survival (RNA) · tumor vs normal (RNA) · all TMCO2 data types