Across TCGA patient cohorts, TMCO2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCO2-associated genes across cancer lineages are EGFR_pY1068, IGFBP2, and Myosin-IIa. Each is linked with TMCO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCO2-to-partner and partner-to-TMCO2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO2→partner) and Y-score (partner→TMCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.320	-3.000	.027	.037	3	1
UCEC	IGFBP2 →	-0.863	-3.000	.021	.037	3	1
UCEC	Myosin-IIa →	+0.255	+2.814	.024	.036	3	1
UCEC	PDCD4 →	-0.814	-2.990	.002	.036	3	1
UCEC	Annexin-1 →	+0.645	+3.000	.034	.037	1	1
UCEC	Shc_pY317 →	-0.277	-3.000	.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

TMCO2 survival (RNA) · tumor vs normal (RNA) · all TMCO2 data types