Across TCGA pan-cancer cohorts, TMCO1-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TMCO1-AS1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TMCO1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMCO1-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and BRCA show a favorable association.

LIHC, STAD, and OV are the cancer types where TMCO1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.458	0.624	<.001	68	view →
STAD	OS	Tertile	IV	0.175	0.693	.002	36	view →
OV	OS	Quartile	IV	0.536	0.208	.005	32	view →
KIRP	DFS	Quartile	All	0.739	0.912	.002	30	view →
MESO	DFS	Tertile	All	0.129	0.688	.001	27	view →
ACC	DFS	Tertile	All	0.185	0.593	.002	24	view →
BLCA	DFS	Median	IV	0.301	0.577	.015	20	view →
BRCA	DFS	Quartile	IV	0.730	0.192	.016	18	view →
UCS	OS	Tertile	II,III,IV	0.823	0.379	.006	16	view →
PAAD	OS	Median	All	0.487	0.210	.003	15	view →
UVM	OS	Median	All	0.499	0.853	.013	15	view →
ESCA	DFS	Tertile	All	1.000	0.386	.009	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: TMCO1-AS1 tumor-vs-normal RNA expression · all TMCO1-AS1 data types