TMCC3

Across TCGA pan-cancer cohorts, TMCC3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TMCC3 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TMCC3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMCC3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and UCEC are the cancer types where TMCC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.915	0.561	<.001	34	view →
PDAC	DFS	Tertile	III,IV	1.000	0.416	.001	25	view →
UCEC	OS	Median	All	0.845	0.975	.012	10	view →
GBM	OS	Quartile	All	0.739	0.391	.006	4	view →
HNSC	OS	Quartile	IV	0.965	0.638	.007	2	view →
CCRCC	DFS	Median	III,IV	1.000	0.451	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TMCC3–LSCC (DFS)

Open the LSCC breakdown →