TMCC3

Across TCGA patient cohorts, TMCC3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCC3-associated genes across cancer lineages are Annexin-1, S6_pS240_S244, and ATM. Each is linked with TMCC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCC3-to-partner and partner-to-TMCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by TMCC3-low versus TMCC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCC3→partner) and Y-score (partner→TMCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.478	+2.341	.018	.019	3	2
UCEC	S6_pS240_S244 →	+0.373	+2.584	.016	.001	3	2
UCEC	ATM →	-0.475	-2.459	.006	.019	3	2
LUSC	c-Myc →	+0.497	+2.816	<.001	.036	3	1
SKCM	EGFR_pY1173 →	-0.101	-2.987	.036	.035	3	1
SKCM	GSK3-a-b →	+0.168	+2.840	.037	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Annexin-1 by TMCC3 expression — UCEC

Explore this box plot interactively →