TMCC3

Across TCGA cell cohorts, TMCC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,896 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMCC3-associated GO terms across cancer lineages are Regulation of establishment of blood-brain barrier, Protein localization to plasma membrane, and Cellular response to external stimulus. Each is linked with TMCC3 in more than 7 cancer types. Because this analysis shows association rather than direction, both TMCC3-to-partner and partner-to-TMCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of establishment of blood-brain barrier grouped by TMCC3-low versus TMCC3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCC3→partner) and Y-score (partner→TMCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of establishment of blood-brain barrier →	-1.131	-1.073	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Protein localization to plasma membrane →	+0.066	+1.168	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Cellular response to external stimulus →	+0.068	+1.017	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of cytokine-mediated signaling pathway →	+0.080	+0.950	.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Activation of innate immune response →	+0.067	+0.962	<.001	<.001	3	7
LUNG_NSCLC_LUSC	Protein localization to cell periphery →	+0.062	+1.471	.002	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,896 associations by consensus.

Regulation of establishment of blood-brain barrier by TMCC3 expression — CNS

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