TMCC2

Across TCGA patient cohorts, TMCC2 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCC2-associated genes across cancer lineages are ATM, Smad4, and TIGAR. Each is linked with TMCC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMCC2-to-partner and partner-to-TMCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TMCC2-low versus TMCC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCC2→partner) and Y-score (partner→TMCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.615	-2.893	<.001	.001	3	3
STAD	Smad4 →	+0.149	+3.169	.004	.019	3	2
STAD	TIGAR →	+0.465	+3.169	.021	.019	3	2
COAD	A-Raf_pS299 →	-0.189	-2.982	.010	.034	3	2
COAD	INPP4B →	-0.340	-3.576	.036	.002	3	2
UCEC	MEK1 →	+0.423	+2.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

ATM by TMCC2 expression — UCEC

Explore this box plot interactively →