TMCC2

Across TCGA cell cohorts, TMCC2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMCC2-associated genes across cancer lineages are MS4A10, SYCN, and LPA. Each is linked with TMCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCC2-to-partner and partner-to-TMCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A10 grouped by TMCC2-low versus TMCC2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCC2→partner) and Y-score (partner→TMCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	2
BLOOD_Leukemia	SYCN →	+0.037	+4.539	<.001	.007	3	2
LARGE_INTESTINE	LPA →	+0.148	+3.887	<.001	.001	3	1
LUNG_NSCLC_LUAD	RBMY1A1 →	+1.074	+4.371	<.001	.005	3	1
BLOOD_Leukemia	CCKAR →	+0.043	+4.409	<.001	.005	3	1
BLOOD_Leukemia	CCT8L2 →	+0.014	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MS4A10 by TMCC2 expression — OVARY

Explore this box plot interactively →