Across TCGA pan-cancer cohorts, TMCC2-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TMCC2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMCC2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types TMCC2-AS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, HNSC, and LUSC are the cancer types where TMCC2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMCC2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.030	.017	2	view →
HNSC	Male	II,III,IV	+0.029	.038	2	view →
LUSC	All	All	+0.027	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TMCC2-AS1 RNA expression & survival · all TMCC2-AS1 data types