TMCC1

Across TCGA pan-cancer cohorts, TMCC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMCC1 data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMCC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TMCC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where TMCC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.945	0.780	<.001	31	view →
PDAC	DFS	Quartile	II,III,IV	0.467	0.875	.027	7	view →
CCRCC	DFS	Quartile	All	0.630	1.000	.031	4	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
LSCC	DFS	Median	II,III,IV	0.873	0.691	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TMCC1–HNSC (OS)

Open the HNSC breakdown →