TMCC1

Across TCGA patient cohorts, TMCC1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCC1-associated genes across cancer lineages are eIF4E, Chk1, and Notch1. Each is linked with TMCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCC1-to-partner and partner-to-TMCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TMCC1-low versus TMCC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCC1→partner) and Y-score (partner→TMCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.290	+2.832	.003	.035	3	2
COAD	Chk1 →	+0.420	+2.815	<.001	.036	3	2
UCEC	Notch1 →	+0.146	+3.594	.008	.001	3	2
UCEC	PCNA →	+0.200	+1.584	.018	.036	3	2
UCEC	PDCD4 →	-0.530	-2.999	.004	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.699	+2.019	.002	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by TMCC1 expression — COAD

Explore this box plot interactively →