TMC8

Across TCGA patient cohorts, TMC8 protein abundance is significantly associated with the RNA expression of many other genes, with 1,301 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMC8-associated genes across cancer lineages are MEFV, EBI3, and DENND3. Each is linked with TMC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC8-to-partner and partner-to-TMC8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMC8 versus MEFV in LSCC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC8→partner) and Y-score (partner→TMC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEFV →	+0.634	+0.545	<.001	<.001	3	2
LUAD	EBI3 →	+0.803	+0.587	.003	.002	3	2
LUAD	DENND3 →	+0.519	+0.466	.001	.004	3	2
LSCC	VNN2 →	+1.016	+0.645	<.001	<.001	3	2
LUAD	MYBPC3 →	+0.406	+0.460	.001	.005	3	2
LUAD	PLCL2 →	+0.667	+0.534	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,301 associations by consensus.

TMC8 vs MEFV — LSCC

Explore this scatter interactively →