TMC8

Across TCGA patient cohorts, TMC8 mutation is significantly associated with the RNA expression of many other genes, with 1,508 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC8-associated genes across cancer lineages are LIN7C, GPATCH11, and SUPV3L1. Each is linked with TMC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC8-to-partner and partner-to-TMC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIN7C grouped by TMC8-low versus TMC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC8→partner) and Y-score (partner→TMC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIN7C →	+0.519	+3.467	.007	.002	3	2
UCEC	GPATCH11 →	+0.459	+2.628	.002	.005	3	2
UCEC	SUPV3L1 →	+0.403	+3.098	.004	<.001	3	2
UCEC	NTAN1 →	+0.529	+2.724	<.001	.003	3	2
UCEC	BOLA3 →	+0.401	+1.949	.005	.009	3	2
UCEC	MRPS18C →	+0.407	+3.467	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,508 associations by consensus.

LIN7C by TMC8 expression — UCEC

Explore this box plot interactively →