TMC8

Across TCGA patient cohorts, TMC8 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC8-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ERK2. Each is linked with TMC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC8-to-partner and partner-to-TMC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TMC8-low versus TMC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC8→partner) and Y-score (partner→TMC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.129	-3.143	.004	.018	3	1
UCEC	EGFR_pY1068 →	-0.243	-2.700	.031	.006	3	1
UCEC	ERK2 →	+0.217	+3.169	.012	.018	3	1
UCEC	HER3 →	-0.251	-2.687	.043	.006	3	1
UCEC	Ku80 →	+0.235	+2.013	.027	.018	3	1
UCEC	PCNA →	+0.198	+2.000	.042	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by TMC8 expression — UCEC

Explore this box plot interactively →