TMC8

Across TCGA cell cohorts, TMC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,950 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMC8-associated GO terms across cancer lineages are Small GTPase-mediated signal transduction, Rho protein signal transduction, and Amino sugar catabolic process. Each is linked with TMC8 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMC8-to-partner and partner-to-TMC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Small GTPase-mediated signal transduction grouped by TMC8-low versus TMC8-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC8→partner) and Y-score (partner→TMC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Small GTPase-mediated signal transduction →	+0.051	+1.234	.004	.005	3	9
LUNG_NSCLC_LUAD	Rho protein signal transduction →	+0.100	+0.850	<.001	.005	3	9
BREAST	Amino sugar catabolic process →	-0.133	-0.768	.002	.007	3	9
OESOPHAGUS	Late endosome to lysosome transport →	+0.162	+1.167	<.001	<.001	3	8
OESOPHAGUS	Negative regulation of supramolecular fiber organization →	+0.093	+1.246	.005	.002	2	9
OVARY	Negative regulation of actin filament bundle assembly →	+0.097	+0.640	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,950 associations by consensus.

Small GTPase-mediated signal transduction by TMC8 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →