TMC8

Across TCGA cell cohorts, TMC8 mutation is significantly associated with the RNA expression of many other genes, with 198 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMC8-associated genes across cancer lineages are IFNA5, KRTAP17-1, and MSGN1. Each is linked with TMC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC8-to-partner and partner-to-TMC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA5 grouped by TMC8-low versus TMC8-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC8→partner) and Y-score (partner→TMC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFNA5 →	+0.022	+4.882	<.001	.001	3	1
SOFT_TISSUE	KRTAP17-1 →	+0.011	+4.369	<.001	.008	3	1
SKIN	MSGN1 →	+0.090	+6.022	<.001	.001	3	1
SKIN	OR11H6 →	+0.022	+4.977	<.001	.007	3	1
SKIN	KRT25 →	+0.049	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 198 associations by consensus.

IFNA5 by TMC8 expression — SOFT_TISSUE

Explore this box plot interactively →