TMC7

Across TCGA patient cohorts, TMC7 mutation is significantly associated with the RNA expression of many other genes, with 4,134 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC7-associated genes across cancer lineages are RNA5SP198, RNU6-197P, and MIR124-2. Each is linked with TMC7 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC7-to-partner and partner-to-TMC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP198 grouped by TMC7-low versus TMC7-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC7→partner) and Y-score (partner→TMC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP198 →	+0.381	+4.559	<.001	.006	3	3
SARC	RNU6-197P →	+0.429	+5.345	<.001	.005	3	3
UCEC	MIR124-2 →	+0.107	+3.620	<.001	.009	3	3
UCEC	RNA5SP413 →	+1.249	+1.997	<.001	<.001	3	3
HNSC	RN7SL132P →	+0.292	+5.310	.004	.001	3	3
PRAD	MIR6075 →	+0.653	+5.109	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,134 associations by consensus.

RNA5SP198 by TMC7 expression — CESC

Explore this box plot interactively →