TMC7

Across TCGA patient cohorts, TMC7 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC7-associated genes across cancer lineages are p38-MAPK_pT180_Y182, MSH2, and S6_pS240_S244. Each is linked with TMC7 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC7-to-partner and partner-to-TMC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by TMC7-low versus TMC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC7→partner) and Y-score (partner→TMC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.404	-1.501	.008	.015	3	3
UCEC	MSH2 →	-0.281	-3.880	<.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.281	+3.013	.042	.018	3	2
UCEC	TFRC →	+0.660	+2.807	<.001	.003	3	2
SKCM	INPP4B →	-0.126	-3.459	.049	.004	3	2
UCEC	14-3-3_beta →	-0.084	-2.195	.014	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

p38-MAPK_pT180_Y182 by TMC7 expression — UCEC

Explore this box plot interactively →