TMC6

Across TCGA patient cohorts, TMC6 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC6-associated genes across cancer lineages are eIF4E, ATM, and Bax. Each is linked with TMC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC6-to-partner and partner-to-TMC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TMC6-low versus TMC6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC6→partner) and Y-score (partner→TMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.277	+2.334	<.001	.018	3	3
UCEC	ATM →	-0.449	-3.687	.004	.001	3	3
COAD	Bax →	+0.266	+3.000	.006	.035	3	3
COAD	MIG-6 →	+0.100	+3.182	.020	.009	3	3
COAD	EGFR_pY1068 →	-0.366	-2.450	.010	.020	3	2
UCEC	ACC1 →	+0.252	+1.750	.045	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

eIF4E by TMC6 expression — COAD

Explore this box plot interactively →