TMC6

Across TCGA cell cohorts, TMC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,640 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMC6-associated GO terms across cancer lineages are Micturition, Cytotoxic T cell degranulation, and Cellular response to alcohol. Each is linked with TMC6 in more than 13 cancer types. Because this analysis shows association rather than direction, both TMC6-to-partner and partner-to-TMC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Micturition grouped by TMC6-low versus TMC6-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC6→partner) and Y-score (partner→TMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Micturition →	-1.939	-3.709	.003	<.001	3	14
BONE	Cytotoxic T cell degranulation →	+0.281	+2.413	<.001	<.001	3	13
LIVER	Cellular response to alcohol →	+0.105	+2.795	.001	.002	3	13
LIVER	Establishment of epithelial cell apical/basal polarity →	-0.201	-2.702	.007	.007	3	12
URINARY_TRACT	Regulation of clathrin coat assembly →	+0.315	+2.843	<.001	<.001	3	11
OVARY	T cell mediated cytotoxicity →	+0.240	+2.064	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,640 associations by consensus.

Micturition by TMC6 expression — LIVER

Explore this box plot interactively →