TMC5

Across TCGA pan-cancer cohorts, TMC5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMC5 data layer compared with 20 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TMC5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMC5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, UCEC, and LSCC are the cancer types where TMC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.291	0.507	.009	16	view →
UCEC	DFS	Median	All	0.937	0.765	.008	12	view →
LSCC	DFS	Median	II,III,IV	0.569	0.820	.013	6	view →
HNSC	DFS	Tertile	IV	1.000	0.566	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMC5–PDAC (DFS)

Open the PDAC breakdown →