TMC5

Across TCGA patient cohorts, TMC5 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC5-associated genes across cancer lineages are TFRC, p38-MAPK_pT180_Y182, and PKC-b-II_pS660. Each is linked with TMC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC5-to-partner and partner-to-TMC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by TMC5-low versus TMC5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC5→partner) and Y-score (partner→TMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TFRC →	+0.609	+3.025	.027	.019	3	3
SKCM	p38-MAPK_pT180_Y182 →	-0.196	-1.375	.020	.013	3	3
UCEC	PKC-b-II_pS660 →	-0.194	-1.378	.019	.008	3	3
SKCM	CDK1 →	+0.129	+1.000	.002	.025	3	3
UCEC	FOXO3a_pS318_S321 →	-0.100	-1.504	.007	.014	3	3
UCEC	ASNS →	+0.317	+1.999	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

TFRC by TMC5 expression — COAD

Explore this box plot interactively →