TMC5

Across TCGA cell cohorts, TMC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,969 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible TMC5-associated GO terms across cancer lineages are Regulation of blood-brain barrier permeability, Negative regulation of myeloid leukocyte mediated immunity, and Negative regulation of chemokine production. Each is linked with TMC5 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMC5-to-partner and partner-to-TMC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of blood-brain barrier permeability grouped by TMC5-low versus TMC5-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC5→partner) and Y-score (partner→TMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of blood-brain barrier permeability →	+0.290	+2.625	<.001	<.001	3	9
STOMACH	Negative regulation of myeloid leukocyte mediated immunity →	+1.845	+3.702	<.001	<.001	3	9
PANCREAS	Negative regulation of chemokine production →	+0.134	+2.933	.001	<.001	3	9
OESOPHAGUS	Sensory perception of salty taste →	+0.957	+1.806	.002	.007	3	9
OESOPHAGUS	Establishment of endothelial intestinal barrier →	+0.177	+2.445	<.001	<.001	3	9
STOMACH	Response to sterol depletion →	+0.102	+2.736	.003	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,969 associations by consensus.

Regulation of blood-brain barrier permeability by TMC5 expression — PANCREAS

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