TMC5

Across TCGA cell cohorts, TMC5 mutation is significantly associated with the RNA expression of many other genes, with 170 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMC5-associated genes across cancer lineages are HACD1, CLPSL1, and PGK2. Each is linked with TMC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC5-to-partner and partner-to-TMC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HACD1 grouped by TMC5-low versus TMC5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC5→partner) and Y-score (partner→TMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HACD1 →	+1.064	+2.850	.002	<.001	3	2
BLOOD_Leukemia	CLPSL1 →	+0.044	+5.201	<.001	.006	3	2
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	TCP11X2 →	+0.019	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	RETN →	+0.109	+3.949	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PTH2 →	+0.095	+2.896	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 170 associations by consensus.

HACD1 by TMC5 expression — SKIN

Explore this box plot interactively →