Across TCGA patient cohorts, TMC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,007 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMC3-associated proteins across cancer lineages are TXNDC5, MYDGF, and NUCB2. Each is linked with TMC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMC3-to-partner and partner-to-TMC3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC3→partner) and Y-score (partner→TMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TXNDC5 →	+0.618	+0.435	<.001	<.001	3	5
LSCC	MYDGF →	+0.426	+0.387	<.001	<.001	3	5
BRCA	NUCB2 →	+0.595	+1.134	<.001	<.001	3	5
HNSC	SND1 →	+0.205	+0.444	<.001	<.001	3	5
LSCC	GMPPA →	+0.434	+0.416	<.001	<.001	3	5
HNSC	MZB1 →	+0.857	+0.522	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,007 associations by consensus.

Exploration

TMC3 survival (RNA) · tumor vs normal (RNA) · all TMC3 data types